Will skipping the capsule shell affect the efficacy of the medicine? Most capsules should be swallowed whole to ensure that the contents of the medicine are effective. When taking capsules, some people think that the capsule shell is superfluous, or feel that the capsule shell is too big to be swallowed, or think that it is harmful to the human body, so they adopt the method of discarding the capsule and taking the medicine. In fact, this is not correct. of. "The medicines in capsules are some powders or particles that are irritating to the esophagus and gastric mucosa, and some are easily volatilized and cannot be made into tablets, or are lost in the mouth and are easily decomposed by saliva enzymes, or are easily inhaled by mistake in the trachea. "Song Suyi, a pharmacist in charge of the Department of Pharmacy of the First People's Hospital of Zhengzhou, said that these powders or microparticles are packed in capsules, which not only protects the drug’s properties from being destroyed, but also masks the bad smell of the drug, is easy to swallow, and protects the digestive organs. And respiratory tract. Song Suyi said that removing the capsule shell may cause drug loss, drug waste, and reduced efficacy. For example, non-steroidal anti-inflammatory drugs that are more irritating to the stomach may cause gastric mucosal cell damage. In severe cases, they may cause peptic ulcers, bleeding and perforation. After being made into capsules, they protect the digestive organs; another example is Buluo The instructions of the Fen sustained-release capsules recommend that they must be swallowed whole, not opened or dissolved; capsules of digestive enzymes or probiotics must also be swallowed whole. "Sometimes due to the needs of treatment, it is necessary to delay the release of the drug and the targeted release of the drug. The drug can be made into sustained-release granules and filled into capsules as needed to achieve a sustained-release and delayed-effect effect." Song Suyi said, if the drug is peeled off and taken, It may change the efficacy of the drug, or easily cause drug-induced gastritis. For example, the instructions for the sustained-release isosorbide mononitrate capsules used for the long-term treatment of coronary heart disease and angina pectoris record that the drug should be swallowed whole and should not be chewed.