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What do you know about Enteric Gelatin Hollow Capsules?

By admin / Date Feb 06,2023
Typically, the gelatin used in the production of enteric gelatin hollow capsules is bovine or porcine bone gelatin. These gelatins are non-allergenic and non-toxic. It is also easily digested and contributes to the firmness of the capsules.

A gelatin hollow capsule is an enteric hollow capsule that is prepared from the following parts by mass: gelatin, plasticizer, opacifier titanium dioxide, food coloring, hydroxypropyl methylcellulose (HPMC) and 0 to 4 auxiliaries. The enteric coating is then applied. The coating is composed of polymer film-forming substances, anti-adhesion agents, colorants and dispersion agents.
Gelatin dosage forms are safe for use with dietary supplements and medicines. These dosage forms are available in a range of shapes and sizes. They are also customizable to meet the requirements of active fills.

Enteric coating has been used to protect dosage forms in the gastrointestinal tract. It provides delayed release properties and helps to dissolve in the duodenum and the small intestine. It also allows for proper disintegration in alkaline conditions. It has been used in herbal products, nutrient supplements and over-the-counter (OTC) drugs.
Enteric coating can be applied in different ways: fluidized bed coating, electrostatic coating, hot melt coating, and aqueous polymer dispersions. The thickness of the coating can be controlled by controlling the concentration of enteric coating.

Enteric coatings are also used to protect capsules from disintegration in acidic conditions. The thickness of enteric coatings ranges from 12 microns to 18 microns. It can be applied using aqueous polymer dispersions, aqueous-organic emulsions, and organic solvents.